Building on the work of an existing, MRC-funded project examining the contributions of the ZNF804A zinc finger transcription factor locus to brain function in animal models, the work proposed here aims to apply recall studies to expand this effort to detailed examination of parallel human traits, combining the expertise and methods developed in MRC CAiTE with Cardiff's expertise in neuropsychiatric genetics and Bristol/Harvard's expertise in sleep neurophysiology. Crucial to the motivation of this study are the observations that (1) variation at the ZNF804A locus is associated with schizophrenia and related disorders risk and (2) that patients present with abnormalities in neural oscillations during sleep, which in turn cause or reflect cognitive deficits that respond poorly to current therapies. Since distinct patterns of oscillatory neural activity during sleep reflect functioning of well-defined neural circuits, this presents an opportunity to link ZNF804A variants to brain function and thereby rationalize future therapeutic design.