The aim of the current study is to identify genetic variants that influence the risk of Attention Problems

and ADHD in children.

Previous genome-wide association studies on ADHD have not been able to establish genome-wide

significant results, indicating that effect sizes are probably small and that large sample-sizes are needed to

reliably identify genetic risk factors for ADHD, although othe explanations including phenotype

definitions are also possible.

To continue the search for genes underlying variation in Attention problems and ADHD, all cohorts

participating in the EArly Genetics and Lifecourse Epidemiology (EAGLE) Consortium are invited to

perform a genome-wide association analysis on attention problems, ADHD or ADHD-related traits, after

which a meta-analysis will take place. Both an analysis of a continous and a dichotomized trait will be

performed, on parent and teacher ratings of children seperately. Cohorts that do not have genome-wide

data are then invited to perform genotyping of the top SNPs in order to attempt to replicate the results

found in the discovery cohort.