B2098 - Genome-wide analysis of association between genotype and methylation - 24/10/2013
Outline
DNA methylation data has recently been generated from ALSPAC samples at multiple timepoints using the Illumina HM450k DNA methylation array. Comprehensive genotype data also exists for the same samples. This project will integrate these two large-scale datasets to investigate the role of genetic variation in DNA methylation.
Aims
1. Genome-wide association analysis of methylation in children and mothers to identify both cis and trans associations between genetic variants and methylation
2. Analysis of change in genotype/methylation associations through the lifecourse
3. Comparison of genotype/methylation associations to published genotype/phenotype and genotype/outcome associations
4. Comparison of genotype/methylation associations to genotype/expression associations (published and within ALSPAC)
5. Comparison of genotype/methylation assocations to ENCODE regulatory regions
6. Analysis of proportion of methylation variance that is influenced by genotype (cis/trans) and non-genetic factors.
9. Single point genotype-stage interaction analysis
10. Genetic and non-genetic correlation over space and developmental stages.