B2104 - Associations between one-carbon pathway metabolite measures genetic and epigenetic variation within ALSPAC - 05/12/2013

B number: 
B2104
Principal applicant name: 
Dr Edward Mountjoy (University of Bristol, UK)
Co-applicants: 
Dr Nic Timpson (University of Bristol, UK)
Title of project: 
Associations between one-carbon pathway metabolite measures, genetic and epigenetic variation within ALSPAC.
Proposal summary: 

Aims:

1. To detect genetic variants (using GWAS) associated with one-carbon pathway metabolite measures.

2. Investigate how pathway measures are associated with downstream molecular phenotypes (e.g. Epigenetic and metabolic profiles) in the selected subset of individuals.

Date proposal received: 
Monday, 28 October, 2013
Date proposal approved: 
Thursday, 5 December, 2013
Keywords: 
Nutrition
Primary keyword: 
Epigenetics