B2112 - Exploring the fetal insulin hypothesis in ALSPAC - 28/11/2013

B number: 
B2112
Principal applicant name: 
Dr Rebecca Richmond (University of Bristol, UK)
Co-applicants: 
Dr Rachel Freathy (Peninsula Medical School, University of Plymouth, UK), Prof Debbie A Lawlor (University of Bristol, UK), Dr Nic Timpson (University of Bristol, UK), Prof George Davey Smith (University of Bristol, UK)
Title of project: 
Exploring the fetal insulin hypothesis in ALSPAC.
Proposal summary: 

Aims

1) To investigate associations between offspring birthweight and offspring fasting glucose/insulin at birth, age 8.5 years, 15 years and 17 years.

2) To investigate associations between offspring birthweight allele score (known variants and genome wide prediction), birthweight and offspring fasting glucose/insulin

3) To investigate associations between offspring birthweight allele score (known variants and genome wide prediction), birthweight and offspring fasting glucose/insulin - with adjustment for maternal genotype to remove negative confounding.

4) To investigate associations between maternal birthweight and maternal fasting glucose/insulin in FOM1 clinic

5) To investigate associations between maternal birthweight allele score, birthweight and maternal fasting glucose/insulin

6) To investigate associations between offspring glucose/insulin allele score and offspring birthweight

7) To investigate the timing of effect of individual glucose/insulin variants

8) Bivariate GCTA of offspring birthweight and offspring glucose/insulin.

Date proposal received: 
Wednesday, 20 November, 2013
Date proposal approved: 
Thursday, 28 November, 2013
Keywords: 
Primary keyword: 
Diabetes