B2154 - Hypothesis-free Mendelian Randomisation - 06/02/2014
B number:
B2154
Principal applicant name:
Dr Gibran Hemani (University of Bristol, UK)
Co-applicants:
Prof George Davey Smith (University of Bristol, UK)
Title of project:
Hypothesis-free Mendelian Randomisation.
Proposal summary:
In genomics there are lots of non-variable base positions, because if a mutation were to occur there it would be deleterious. But of course there are many polymorphic sites that are deleterious too, and a large number that are potentially selectively neutral or functionally neutral.
An old idea for which GWAS data is now providing new evidence is that complex traits follow the infinitesimal model - where an infinite number sites each with an infinitesimally small effect exist. Of course this is not to be taken literally but the point is, is it the case that a very large number of methylation sites influence complex traits, each with a small effect?
Date proposal received:
Tuesday, 28 January, 2014
Date proposal approved:
Thursday, 6 February, 2014
Keywords:
Epigenetics , Data mining
Primary keyword:
Mendelian Randomisation