B2221 - Maternal function folate status and risk of ASDs in the ALSPAC birth cohort - 10/04/2014
B number:
B2221
Principal applicant name:
Brian K Lee (Drexel University, USA)
Co-applicants:
Dr Dheeraj Rai (University of Bristol, UK), Prof Jean Golding (University of Bristol, UK), Elizabeth A De Vilbiss (Drexel University, USA)
Title of project:
Maternal function folate status and risk of ASDs in the ALSPAC birth cohort
Proposal summary:
Aims
In our proposed work, we aim to investigate relationships between ASD and related traits, and key determinants of functional folate-status in a large, well-characterized birth cohort with prospectively collected data. Determinants of folate-status to be investigated include self-report of maternal folate supplementation at 16 and 32 weeks gestation, dietary folate intake at 32 weeks gestation, child folate intake reported at 1 year of age, as well as maternal and child genetic variants involved in one-carbon metabolism and epigenetic regulation. These determinants are to be investigated both individually, and jointly to assess potential interactions.
Date proposal received:
Saturday, 5 April, 2014
Date proposal approved:
Thursday, 10 April, 2014
Keywords:
Genetics, Mendelian Randomisation
Primary keyword:
Autism