Aims:

Low birth weight is linked with an adverse metabolic profile in adulthood and increased risk for cardiometabolic diseases. We aim to elucidate this relationship by examining associations of birthweight with a comprehensive metabolite profiled quantified by high-throughput serum NMR spectroscopy. We will assess associations of birthweight (as continuous measure) with uniform data on serum metabolites in greater than 20,000 individuals from several population-based cohorts from Finland, and would like to include ALSPAC in the analyses. ALSPAC has recently completed high-throughput metabolite profiling by NMR for multiple time-points in both the children and the mothers. The multiple time-points metabolite data in ALSPAC will be examined for effect modulation by age, ie. if effects of birthweight are fixed during adolescence and early adulthood. Similar multiple time-points is available for 2 Finnish cohorts.