B2249 - Identifying the impact of mental disorder risk alleles on childhood neurodevelopment - 05/06/2014
B number:
B2249
Principal applicant name:
Prof Anita Thapar (University of Cardiff, UK)
Co-applicants:
Prof Michael O'Donovan (University of Cardiff, UK), Dr Stephan Collishaw (University of Cardiff, UK), Prof Barbara Maughan (King's College London, UK), Prof George Davey Smith (University of Bristol, UK), Dr Evie Stergiakouli (University of Bristol, UK), Dr Ajay Thapar (University of Cardiff, UK), Prof Gordon Harold (University of Sussex, UK)
Title of project:
Identifying the impact of mental disorder risk alleles on childhood neurodevelopment.
Proposal summary:
Aims
1)We will test the hypotheses that risk alleles in the general population impact on pre-pubertal neurodevelopmental domains involving 1) emotion/mood regulation 2) cognition/learning 3) social cognition/communication and 4) behaviour regulation.
2) Test the hypothesis that mental disorder RP scores that we find to contribute to domains of neurodevelopment at age 7/8 years have longitudinal effects.
3) Test that bullying/victimisation at 7/8 years further predicts longitudinal change in RP score-associated neurodevelopmental domains.
Date proposal received:
Thursday, 29 May, 2014
Date proposal approved:
Thursday, 5 June, 2014
Keywords:
Behavioural Problems, Genetics
Primary keyword:
Mental Health