B2252 - Effect of deviations from expected birth weight on later life cognitive performance and cardiovascular disease - 12/06/2014

B number: 
B2252
Principal applicant name: 
Dr Daniel Corsi (University of Bristol, UK)
Co-applicants: 
Prof George Davey Smith (University of Bristol, UK)
Title of project: 
Effect of deviations from expected birth weight on later life cognitive performance and cardiovascular disease.
Proposal summary: 

Research Objectives:

The purpose of this project is to determine the effect of deviations from expected birth weight on later life outcomes within the ALSPAC cohort. The study will have the following two specific aims:

1. To develop and validate a method of determining expected birth weight9, 10 through the use of a prediction equation to be developed based on the relationship between gestational age, parity, gender, and other maternal characteristics (age, height, weight, smoking status, mother's own birth weight) and birth weight of offspring in the ALSPAC cohort.

2. To relate deviations from expected birth weight to a set of later life outcomes in the ALSPAC cohort including markers of cognitive development and function and cardiovascular disease outcomes.

Date proposal received: 
Friday, 6 June, 2014
Date proposal approved: 
Thursday, 12 June, 2014
Keywords: 
Cardiovascular , Cognitive Function
Primary keyword: 
Fetal Growth