B2262 - A Mendelian Randomisation Study of the effect of dietary milk intake calcium on BMD and metabolomic variables - 26/06/2014
B number:
B2262
Principal applicant name:
Dr Dave Evans (University of Queensland, Australia, ROW)
Co-applicants:
Dr Charles Laurin (University of Notre Dame, Indiana, USA), Dr Jon Tobias (University of Bristol, UK), Dr Kate Northstone (University of Bristol, UK), Dr Gibran Hemani (University of Bristol, UK), Mr John P Kemp (University of Queensland, Australia, ROW), Prof George Davey Smith (University of Bristol, UK)
Title of project:
A Mendelian Randomisation Study of the effect of dietary milk intake & calcium on BMD and metabolomic variables.
Proposal summary:
There is an observational relationship between dietary intake of dairy/calcium and subsequent risk of osteoporosis/BMI. However, many of these studies are observational in nature and thus subject to confounding. We would like to investigate this relationship using Mendelian Randomization in ALSPAC and in other cohorts that contain these data. Our intention is to use variants related to (i) dairy intake, and (ii) calcium intake/levels (as identified through previous GWAS or through GWAS in ALSPAC) to investigate the relationship between these exposures and (i) bone related phenotypes, height, weight and BMI and (ii) metabolomic measures in ALSPAC.
Date proposal received:
Thursday, 19 June, 2014
Date proposal approved:
Thursday, 26 June, 2014
Keywords:
Bones, Nutrition
Primary keyword:
Mendelian Randomisation