As part of the UK10K consortium (B916 and amendments), ALSPAC undertook association studies which included core inflammatory phenotypes (in this case CRP & IL6). In accordance with the replication amendment for these analyses (performed internally and on ALSPAC imputed GWSA data), results were shared with UK10K analysts for the followup of de novo signals. In the absence of novel research findings, it is proposed that these results (aggregated with 9 other study estimates and in this case only based on two SNPs (rs6743376 and rs1542176 ) which followup IL1 work from the Cambridge led initiative on IL1a/b) are shared with an ongoingand phenotypically linked data set.

ALSPAC is one of the only data sets available with GWAS imputed data of this nature and which has fed into UK10K analyses already formulated which can swiftly feed into this research effort on IL1. As such we are requesting that these two loci and their meta-analysis results (of which ALSPAC GWAS replication results (i.e. that applied for here) only play a small part) are fed into the existing meta-analysis.