B2295 - Identification of epigenetic and genetic associations with leukocyte telomere length - 11/09/2014

B number: 
B2295
Principal applicant name: 
Dr Jessica Buxton (UCL Institute of Research Information Service, uk)
Co-applicants: 
Professor Aroon Hingorani (Not used 0, Not used 0), Stephan Beck (UCL Cancer Institute, UK)
Title of project: 
Identification of epigenetic and genetic associations with leukocyte telomere length
Proposal summary: 

Aims:

The overall goal of our planned project is to identify and characterise DNA methylation changes associated with telomere shortening, a biomarker for healthy ageing, and interrogate the potential causal role of these epigenetic variants in disease risk. Within this, the specific Aims for the proposal to work with samples and data from the ARIES collection of ALSPAC participants are as follows:

i) To carry out a pilot investigation of a subset of ARIES DNA samples, to assess the suitability of the MM-qPCR method for measuring mean relative leukocyte telomere length (LTL) in this cohort.

ii) To identify novel epigenetic variants (DNA methylation of CpG sites) associated with LTL.

iii) To identify genetic variants that influence methylation levels at CpG sites associated with LTL

Date proposal received: 
Tuesday, 9 September, 2014
Date proposal approved: 
Thursday, 11 September, 2014
Keywords: 
Epigenetics
Primary keyword: 
Telomere