B2299 - Investigation of cell mixture adjustments in analysis of DNA methylation in cord blood and childrens blood - 25/09/2014
B number:
B2299
Principal applicant name:
Dr Caroline Relton (University of Bristol, UK)
Co-applicants:
Dr So-Youn Shin (University of Bristol, UK), Dr Tom Gaunt (University of Bristol, UK), Andres Houseman (Oregan state University, US)
Title of project:
Investigation of cell mixture adjustments in analysis of DNA methylation in cord blood and children?s blood
Proposal summary:
Aims: To compare performance of existing methods for cell mixture adjustments in analysis of DNA methylation in cord blood and children's blood
Hypothesis: When the reference samples do not match with study samples, reference free methods are more robust than reference based methods.
Variables:
Total cholesterol
HDL-cholesterol
LCL-cholesterol
Triglycerides
Methylations measured on Illumina 450k methylation array (under ARIES project) as well as covariates including Age, Sex, BMI, Smoking, SEP measures
Date proposal received:
Wednesday, 24 September, 2014
Date proposal approved:
Thursday, 25 September, 2014
Keywords:
Methodology
Primary keyword:
Epigenetics