Aims:

To identify individual genetic variants (specifically single nucleotide polymorphisms, SNPs) that are associated with the ability to identify non-happy emotions in the DANVA facial emotion recognition test, controlling for performance on the equivalent test of happy face recognition. Secondarily, to attempt to stratify this analysis by the type of non-happy emotion (angry, fearful, and sad). Thirdly, to test whether variants associated with sensitivity to non-happy emotion in faces are enriched for association with response to cognitive behavioural therapy for anxiety disorders in a separate cohort. Finally, to explore whether the ability to identify non-happy emotion can be predicted by the genetic risk for psychiatric disorders.