B2341 - Role of rare coding variants in speech and language disorder - 20/11/2014

B number: 
B2341
Principal applicant name: 
Diane Newbury (University of Oxford, UK)
Co-applicants: 
Fabiola Ceroni (University of Oxford, UK), Rose Reader (University of Oxford, UK), Dr Silvia Paracchini (University of Oxford, UK)
Title of project: 
Role of rare coding variants in speech and language disorder
Proposal summary: 

AIM - to investigate the contribution of rare coding variants in selected candidate genes to speech and language disorders

BACKGROUND

Our lab investigates genetic contributions to speech and language disorders, primarily within a cohort of families in which at least one child is diagnosed with specific language impairment (The SLI Consortium (SLIC) cohort). Investigations in this cohort have highlighted specific genetic pathways and candidate genes that we believe might be linked to speech and language development. We would like to follow these genes up in more detail in a larger cohort. The effects we have identified are rare coding mutations. In order to follow these up, we therefore need access to a large cohort in which speech and language data and genetic sequencing are readily available.

Date proposal received: 
Tuesday, 18 November, 2014
Date proposal approved: 
Thursday, 20 November, 2014
Keywords: 
Behavioural Problems
Primary keyword: 
Speech and Language