This project aims at combining multiple MRI datasets obtained in the same magnet (scanner) through very similar acquisiton procedures in order to investigate the association between anatomical markers and genetic risk factors for major mental disorders (psychosis, bipolar disorder and Alzheimer's disease) and associated polygenic pathway scores (e.g. dopaminergic transmission) in healthy participants. The combination of ALSPAC's and our own samples will constitute a unique resource to investigate neuroimaging and genetic associations, since it will include data from potentially up to 1,000 participants avoiding the counfounds of previous similar efforts from other groups using different magnets and not always equivalent data acquisition methods.