B2418 - EWAS of IL6 - 16/04/2015

B number: 
B2418
Principal applicant name: 
Dr Lavinia Paternoster (University of Bristol, UK)
Co-applicants: 
Ruth Mitchell (University of Bristol, UK)
Title of project: 
EWAS of IL6
Proposal summary: 

IL-6 is an inflammatory cytokine with diverse roles in chromic inflammation and autoimmunity. It is thought to play a role in a diverse array of health outcomes, including auto-immune conditions, allergic conditions, brain diseases and even depression. Therefore, increased understanding of the mechanisms that influence it, and that it influences, could have far reaching health implications.

Aim: EWAS of interleukin-6 measured in the children at age 9, to identify CpG sites where methylation levels are correlated with IL-6 levels.

Date proposal received: 
Friday, 10 April, 2015
Date proposal approved: 
Thursday, 16 April, 2015
Keywords: 
Mendelian Randomisation
Primary keyword: 
Epigenetics