B2534 - Assessing causality in the association between maternal pre-pregnancy obesity and child neurodevelopment observational - 02/10/2015

B number: 
B2534
Principal applicant name: 
Dr Martine Vrjheid (Centre for Research in Environmental Epidemiology (CREAL), Europe)
Co-applicants: 
Dr Maribel Casas Sanahuja (Centre for Research in Environmental Epidemiology (CREAL), Europe), Prof Debbie A Lawlor (University of Bristol, UK)
Title of project: 
Assessing causality in the association between maternal pre-pregnancy obesity and child neurodevelopment: observational
Proposal summary: 

Aims: to assess causality in the association between maternal pre-pregnancy body mass index and child neuropsychological by performing an observational analysis of birth cohorts (meta-analysis) and a mendelian randomization (MR) analysis in those cohorts with genetic data available. Further, we will use paternal BMI as a negative control exposure and test the role of the child BMI genetic score.

Date proposal received: 
Tuesday, 15 September, 2015
Date proposal approved: 
Friday, 2 October, 2015
Keywords: 
Mendelian Randomisation, Pregnancy
Primary keyword: 
Obesity