Proposal summaries

These are research proposals that have been approved by the ALSPAC exec. The titles include a B number which identifies the proposal and the date on which the proposals received ALSPAC exec approval.

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B3075 - Genetic vulnerability to schizophrenia and major depressive disorder and the risk of childhood adversities - 08/03/2018

B number: 
B3075
Principal applicant name: 
Henning Tiemeier | Erasmus Medical Center, Rotterdam (The Netherlands)
Co-applicants: 
Title of project: 
Genetic vulnerability to schizophrenia and major depressive disorder and the risk of childhood adversities
Proposal summary: 

Since the recent publication of large genetic studies to identify genetic risk factors for debilitating psychiatric disorders such as schizophrenia and depression, it has been possible to use this genetic information to study to what extent genetic risk to, for example, schizophrenia or depression predict risk for psychiatric problems prior to the development of clinical disorders. Particularly interesting is to investigate how a child's genetics make him or her more vulnerable to the exposure of stressful life events. Moreover, it is still unclear to what extent this relationship mediates the association between genetic risk and childhood psychiatric problems.

Impact of research: 
Date proposal received: 
Monday, 26 February, 2018
Keywords: 
Mental health - Psychology, Psychiatry, Cognition, Mental health, GWAS, Childhood - childcare, childhood adversity, Genetic epidemiology

B3093 - Traits phenotypes and prognosis of childhood asthma - 29/03/2018

B number: 
B3093
Principal applicant name: 
John Henderson | PHS, Bristol Medical School (UK)
Co-applicants: 
Prof Claudia Kuehni, Ben Spycher
Title of project: 
Traits, phenotypes and prognosis of childhood asthma
Proposal summary: 

The proposal is to continue the collaborative work we have been doing with this Swiss group over the past few years. Ben Spycher was a Marie Curie Fellow who worked with ALSPAC data previously. Prof Kuehni leads eth Leicester Asthma Cohorts and has established the Swiss Paediatric Airway Cohort (SPAC). OUr joint objective is to discover influences that determine the onset and progression of asthma in children, how asthma varies between individuals in type and severity and whether we can predict the outcome of asthma using individuals' information. The data in eth Leicester adn Swiss cohorts is complementary to data held in ALSPAC and we have had joint publications where ALSPAC is able to replicate findings in the other cohorts run by the Swiss group.

Impact of research: 
THere have been several attempts to produce an asthma risk score to address the question most parents of wheezy children ask of clinicians. Many of these have reasonable predictive ability but rely on variables that are not routinely measured in clinical practice. If a scoring tool can be developed that has utility in primary care, it will have a major impact on ability to detect children at high risk fo asthma and target them for early intervention.
Date proposal received: 
Thursday, 29 March, 2018
Keywords: 
Clinical research/clinical practice, Respiratory - asthma, Statistical methods, Statistical methods

B3104 - Impact of Breastfeeding on Cardiovascular and Metabolic Outcomes in Women with a History of Hypertensive Disorders of Pregnancy - 26/04/2018

B number: 
B3104
Principal applicant name: 
Abigail Fraser | MRC IEU, University of Bristol
Co-applicants: 
Dr. Jill Demirci, Dr. Janet Catov, Dr. Mandy Schmella
Title of project: 
Impact of Breastfeeding on Cardiovascular and Metabolic Outcomes in Women with a History of Hypertensive Disorders of Pregnancy
Proposal summary: 

Women who experience a hypertensive disorder of pregnancy are at greater risk for diseases of the heart and blood vessels. Breastfeeding may reduce this risk in women in general and particularly in those who have had a hypertensive disorder of pregnancy. This proposed study will examine if the duration/amount of breastfeeding has a beneficial effect on markers of heart health in later life in women who did and did not develop a hypertensive disorder of pregnancy.

Impact of research: 
Knowledge gained from this study will provide insight into whether or not breastfeeding is cardio-protective in women with hypertensive disorders of pregnancy. If we find that breastfeeding has a cardio-protective effect in this high risk population, this could inform intervention design, policy, and breastfeeding promotion efforts among women who develop or who are at risk of developing hypertensive disorders of pregnancy
Date proposal received: 
Thursday, 26 April, 2018
Keywords: 
Epidemiology, Hypertension, Pregnancy - e.g. reproductive health, postnatal depression, birth outcomes, etc., Statistical methods, Biomarkers - e.g. cotinine, fatty acids, haemoglobin, etc., Birth outcomes, Blood pressure, BMI, Breast feeding, Cardiovascular, Nutrition - breast feeding, diet

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