B3818 - Epigenome-wide association study of depression and antidepressant use - 05/07/2021

B number: 
Principal applicant name: 
Doretta Caramaschi | MRC IEU
Alex Kwong, Ms Holly Fraser
Title of project: 
Epigenome-wide association study of depression and antidepressant use
Proposal summary: 

At least 7 million adults in the UK are prescribed antidepressants every year. Antidepressant prescriptions in teenagers are rising. In nearly 50% of people on antidepressants the depression symptoms do not improve after the pharmacological treatment. We will investigate the biological pathways that lead to depression by looking at biomarkers in their blood DNA, as well as molecular markers that antidepressant treatments might leave on blood cells in young adults. We will assess antidepressant use in young adults and potential reasons for stopping the medications, with the ultimate aim to explore the possibility of personalized treatment options.

Impact of research: 
Due to the multi-cohort nature of the project (consortium will have a final N of >20000 participants) and the importance of the research questions (depression and antidepressant use) we expect that we will generate conclusive results that will be relevant to a high number of people in the community as well as health professionals.
Date proposal received: 
Monday, 21 June, 2021
Date proposal approved: 
Wednesday, 23 June, 2021
Molecular genetics and genomics, Mental health, Microarrays, Epigenetics