B3595 - Assessing the contribution of poylgenic risk to pediatric lipid levels and longitudinal trends - 14/08/2020

B number: 
B3595
Principal applicant name: 
Shoa L. Clarke, MD, PhD | Stanford University (United States)
Co-applicants: 
Themistocles Assimes, MD, PhD
Title of project: 
Assessing the contribution of poylgenic risk to pediatric lipid levels and longitudinal trends
Proposal summary: 

Genetic studies have found connections between a person's genes and their cholesterol. These studies have been conducted in adults. Cholesterol is much less variable during childhood. We aim to see if the associations seen in adults also extend to children.

Impact of research: 
This work will lead to a better understanding of the polygenic contributions to complex traits, and it will have important implications for defining the emerging entity of "polygenic familial hypercholesterolemia."
Date proposal received: 
Wednesday, 12 August, 2020
Date proposal approved: 
Friday, 14 August, 2020
Keywords: 
Genetic epidemiology (including association studies and mendelian randomisation), Dyslipidemia and hypercholesterolemia, Statistical methods, Genetic epidemiology