B3405 - DNA methylation signatures of aggressive behavior - 11/11/2019

B number: 
B3405
Principal applicant name: 
Matthew Suderman | IEU (United Kingdom)
Co-applicants: 
Title of project: 
DNA methylation signatures of aggressive behavior
Proposal summary: 

DNA methylation signatures of aggressive behavior may capture lifetime trait dynamics and environmental exposures. DNA methylation in peripheral blood is known to be associated with a variety of exposures (e.g. cigarette smoking) and traits (e.g. BMI). We propose to determine if DNA methylation is associated with aggressive behavior to better understand the biological correlates of aggression and to evaluate the potential utility of aggression biomarkers in peripheral blood.

Impact of research: 
A publication presenting the best biomarkers from peripheral blood DNA methylation to date for aggression. These will be used to better understand the biological correlates of aggression as well as to understand molecular associations with other phenotypes and exposures.
Date proposal received: 
Friday, 8 November, 2019
Date proposal approved: 
Monday, 11 November, 2019
Keywords: 
Genetic epidemiology (including association studies and mendelian randomisation), Behaviour - e.g. antisocial behaviour, risk behaviour, etc., Statistical methods, Biomarkers - e.g. cotinine, fatty acids, haemoglobin, etc., Epigenetics, Genomics