Scoliosis (spinal curvature) is an important condition that can be associated with pain and loss of function, but little is known about the causes of scoliosis. Previous work by our group using zebrafish, has shown that inflammation is one potential cause. However, the link between inflammation and scoliosis has never been examined in humans. We are proposing a project to do this using ALSPAC because data on inflammation and scoliosis has already been collected. Our research group consists of the scientists who originally identified inflammation as potentially important in zebrafish, plus the researchers who developed the method to measure scoliosis in ALSPAC.