B3354 - Understanding the evolution of joint hypermobility pain and associated symptoms a novel multigenerational longitudinal cohort - 22/08/2019

B number: 
B3354
Principal applicant name: 
Emma Clark | University of Bristol (UK)
Co-applicants: 
Prof Nic Timpson, Prof Andy Judge, Prof Shea Palmer
Title of project: 
Understanding the evolution of joint hypermobility, pain and associated symptoms: a novel multigenerational longitudinal cohort
Proposal summary: 
Impact of research: 
1. Improved understanding of the natural history of musculoskeletal hypermobility at a population level 2. Clearer understanding of the association between hypermobility and pain, and whether there are any potentially modifiable effect modifyers such as obesity. 3. Clearer understanding of whether symptoms such as fatigue, urinary symptoms, gastrointestinal symptoms, gynaecological symptoms, anxiety and depression at aged 30 more common in those with hypermobility 4. the ability to give patients more accurate information on the hereditary nature of benign musculoskeletal hypermobility
Date proposal received: 
Wednesday, 7 August, 2019
Date proposal approved: 
Friday, 9 August, 2019
Keywords: 
Epidemiology, Bone disorders - arthritis, osteoporosis, Gastrointestinal, Incontinence, Mental health, Obesity, Pain, Statistical methods, Ageing, BMI, Bones (and joints), Development, Genetic epidemiology, Mendelian randomisation