B3348 - Testing a model of whether early non-specific symptoms independently predict unhealthy lifestyle behaviours and psychosis - 06/08/2019

B number: 
B3348
Principal applicant name: 
Richard Drake | University of Manchester (United Kingdom)
Co-applicants: 
Professor Alison Yung, Miss Alexandra Berry, Miss Rebecca White, Dr. Filippo Varese, Prof. Gillian Haddock, Prof. Richard Bentall , Dr. Maria Haarmans
Title of project: 
Testing a model of whether early non-specific symptoms independently predict unhealthy lifestyle behaviours and psychosis
Proposal summary: 

Psychosis refers to the experience of hallucinations and/or delusions. Psychotic experiences range from short-lived symptoms that are not fully believed through to persistent severe symptoms that characterise psychotic illnesses as schizophrenia. It is well established that enduring psychotic illnesses such as schizophrenia have worse physical health than the general population, and are at an increased risk of developing long-term physical health conditions such as diabetes and heart disease. This may be due to unhealthy lifestyle behaviours, such as a lack of physical activity and smoking. Such risk factors begin early in first-episode psychosis and even before the first episode. However, the causal relationship between poor physical health and psychosis is not fully understood. We think poor physical health and psychosis may occur independently of each other, but are both related to earlier more common mental health difficulties, such as depression and anxiety.
Not everyone who experiences mental health difficulties will go on to develop psychosis or physical health problems. For those who do, recovery is possible. Medication and supportive relationships are known to help with recovery, however less is known about the role of romantic relationships specifically.
This research project aims to explore how these factors interact over time within the ALSPAC dataset.

Impact of research: 
The evidence gained from this project will provide clinically important novel insights into the relationship between non-specific mental health problems and unhealthy lifestyle behaviours, physical morbidity, social relationships and psychosis. The findings of this project will have direct implications for the design of interventions relating to what may be early predictors of psychosis and physical morbidity: depression, anxiety and negative symptoms. Additionally this project will provide an understanding about the role social and in particular, romantic relationships play in the development of psychosis and physical health difficulties. Additionally, if romantic relationships are found to moderate the associations in this model, this may provide an incentive for services to review their approach to and provision of support in this area. Therefore, the outputs of this project potentially have implications for mental and public health services and could ultimately result in changes to the time frame of interventions. We therefore expect this project will result in highly cited academic publications as well as translational impact on clinical practice.
Date proposal received: 
Wednesday, 31 July, 2019
Date proposal approved: 
Tuesday, 6 August, 2019
Keywords: 
Mental health - Psychology, Psychiatry, Cognition, Behaviour - e.g. antisocial behaviour, risk behaviour, etc., Mental health, Statistical methods, BMI, Cardiovascular, Metabolic - metabolism, Physical - activity, fitness, function, Sleep, Statistical methods, psychosis, relationships, mental health, depression, anxiety, smoking