B278 - Identification of genetic roots of coronary artery disease by combining stepwise genome wide association studies with trascriptomic and functional genomic investigation of relevant genetic variants - 01/12/2005

B number: 
B278
Principal applicant name: 
Prof Nilesh Samani (University of Leicester, UK)
Co-applicants: 
Title of project: 
Identification of genetic roots of coronary artery disease by combining stepwise genome wide association studies with trascriptomic and functional genomic investigation of relevant genetic variants,
Proposal summary: 

The main scientific and technological objectives of this highly focused RTD project are:

* to carry out well-integrated genome-wide and functional genomics research in order:

o to identify genetic risk markers for CAD

o to link these with transcriptome data and cellular function in atherosclerosis

o to discover new candidates and systems for drug development

o to exploit Intellectual Property Rights (IPR) in partnership with SMEs and the pharmaceutical industry

o to develop integrated novel information systems

* to establish a world-leading European consortium on the basis of genuine and equal partnership between leading clinical centres, academic groups, cell biologists, bioinformaticians and biostatisticians to provide further knowledge into the genetic basis of CAD for the benefit of members of the European Community.

Date proposal received: 
Thursday, 1 December, 2005
Date proposal approved: 
Thursday, 1 December, 2005
Keywords: 
Cardiovascular , Genetics
Primary keyword: